SCOPE
Compound Toxicity Profile (CTP) is part of SAFETY BY DESIGN ® service and consists of statistical toxicity models that generate profiles for chemicals and subsequent toxicity alerts in diverse areas :
- Neurotoxicity
- Reprotoxicity
- Carcinogenicity
- Mutagenicity
- Endocrine disruption
- Persistent, Bioaccumulative and Toxic (PBT) behavior
- Respiratory sensitization
- Acute toxicity
APPLICATION
We address the needs of clients, subject or not to the REACH regulation, by providing a rationale to support decision-making processes :
- Generate toxicity alerts : statistical QSAR models are trained to recognize compounds with a toxicity issue based on structural descriptors
- Prioritize the most promising compounds at an early stage by discarding chemicals with toxicity bottlenecks
- Substitute compounds for more compliant ones : Our models can also be used to select a safer compound in a more advanced development stage
BENEFITS
By ensuring safety of chemicals, we provide additional pieces of a rationale for making decisions :
- Reduce overall costs of development by supporting decisions at critical stages
- Comply with the REACH and other regulations
- Comply with the trend of less animal testing
For more details : https://objectivation-en.harmonicpharma.com/